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Orr, Miranda

One or more keywords matched the following items that are connected to Orr, Miranda

Item Type	Name
Concept	Oxidative Stress
Concept	Transgenes
Concept	Synapses
Concept	Alzheimer Disease
Concept	Saccharomyces cerevisiae Proteins
Concept	Sirolimus
Concept	Neurodegenerative Diseases
Concept	Synaptic Transmission
Concept	Saccharomyces cerevisiae
Concept	Intracellular Signaling Peptides and Proteins
Concept	Signal Transduction
Concept	Gene Expression Profiling
Concept	Peripheral Nervous System
Concept	Disease Models, Animal
Concept	Magnetic Resonance Spectroscopy
Concept	Dietary Sucrose
Concept	Disease Progression
Concept	Amyotrophic Lateral Sclerosis
Concept	Cell Size
Concept	Supranuclear Palsy, Progressive
Academic Article	Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain.
Academic Article	Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.
Academic Article	Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.
Academic Article	Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat.
Academic Article	Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Academic Article	Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.
Academic Article	The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system.
Academic Article	Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology.
Academic Article	Autophagic/lysosomal dysfunction in Alzheimer's disease.
Academic Article	Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates.
Academic Article	A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.
Academic Article	Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau.
Academic Article	Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes.
Academic Article	Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.
Academic Article	Tau protein aggregation is associated with cellular senescence in the brain.
Grant	Novel Stem Cell and Mouse Models to Study Frontotemporal Dementia
Grant	Alzheimer's Disease Associated Tau Toxicity Induces Cellular Senescence in Brain
Grant	High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of Life
Academic Article	Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).
Academic Article	Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model.
Grant	Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and Symptomatology
Grant	Investigating the Role of Tau Protein in Neuronal Senescence Induction and Maintenance
Grant	Cell Senescence and Death in Neurodegenerative Diseases
Grant	Phase II Clinical Trial to Evaluate the Safety and Feasibility of Senolytic Therapy in Alzheimer’s Disease
Grant	Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's disease
Grant	High Resolution Profiling of Senescent Cells in ALS Brain and Spinal Cord
Grant	Alzheimer’s disease-associated tau toxicity induces cellular senescence in the brain.
Academic Article	Biological aging processes underlying cognitive decline and neurodegenerative disease.
Academic Article	Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
Academic Article	Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application.
Academic Article	Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Academic Article	Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.
Academic Article	The landscape of human tissue and cell type specific expression and co-regulation of senescence genes.
Academic Article	A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials.
Academic Article	The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration.
Academic Article	Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration.
Academic Article	Can oral health and oral-derived biospecimens predict progression of dementia?

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